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RNAi loss-of-function screens, which have proven effective to identify genes functionally responsible for cellular phenotypes, can be designed to use different genetic backgrounds or altered environmental conditions to elucidate genetic dependencies.
DNA markers detecting polymorphisms in genes that are functionally responsible for changes in phenotypes can be called functional markers [ 27, 45].
This study was designed to locate the opiate receptors functionally responsible for this inhibition.
Generally, no individual or group is functionally responsible for overseeing the arrangement of the enterprise from end to end.
The story is told in prose of intermittently easygoing lucidity, but his primary training as a neurologist compels him into passages of detailed neuro-anatomy, locating brain regions functionally responsible for enabling particular aspects of consciousness.
Thereby, rs10336, rs3921, and rs4619915 polymorphisms could be functionally responsible for the observed effect or could just be polymorphisms in high LD with the causal mutation.
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These studies have helped to delineate a number of functionally important loci responsible for the genetic adaptation to high altitude.
(36) Functionally, HDL is responsible for facilitating transport of cholesterol from tissues back to the liver for catabolism through a process known as reverse cholesterol transport.
Functionally relevant variants responsible for mendelian disorders [ 15] and cancer [ 16] have been successfully identified by using the re-sequencing strategy [ 15, 16].
The complicated interactions between functionally associated genes responsible for human complex diseases can, therefore, be traced back to their not-so-deep evolutionary past.
Besides, we have also examined amino acid sequence evolution of the other members of NCS protein family to identify functionally important sites responsible for differentiation between subfamilies.
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