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Functionally, products of subfamily 1 [HKT1 2, HKT1 3, HKT1 4, HKT1;4 and HKT1 5] are Na + specific transporters and have S-G-G-G signature while products of subfamily 2 [HKT2 2, HKT2 3, HKT2;3 and HKT2 4] are Na+-K+ co-transporters or Na+-K+ uniporters with G-G-G-G signature (Jabnoune et al. 2009; Mäser et al. 2002).
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The simplicity metric was developed by using experts' evaluations of functionally equivalent products.
30 participants were shown sixteen pairs of emotionally or functionally designed products while their eye-movements were recorded.
However, design thinking cuts more deeply than producing aesthetically and functionally pleasing products that consumers will buy.
We discuss the possible biological significance in later sections following a subsystems oriented approach that groups orthologous, paralogous and even analogous genes with functionally related products.
Multiple splicing variants derived from orthologous genes may or may not share the same exon/intron organization or encode for functionally equivalent products.
As opposed to other bacterial species with expanded genomes representing gene duplication events [ 9], the genome of P. aeruginosa is made up of an assortment of genes encoding functionally diverse products.
Alternatively, clustering of genes could be explained by coinheritance, a selective pressure to maintain a genetic linkage among genes that encode for functionally related products and that will tend to be inherited together or, finally, it could merely reflect the origin of functionally related genes via tandem duplication of genes [ 6, 7].
It is more likely that orthologous splicing variants encode functionally equivalent products, while transcripts with a different exon-intron structure (e.g. differing in the number and/or length of exons) may encode products with different functional features and/or subject to different post-transcriptional regulation.
In the field of design, it is accepted that users' perceptions of systems are influenced by emotion as much as cognition, and functionally-complete products will not be adopted if they do not appeal to emotions.
Similar opportunities for divergence in functionally relevant product attributes could emerge for other classes of glycosylated biologics, including monoclonal antibodies subject to future biosimilar competition.
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