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This suggests there are specific factors that influence the activity of SP-PrP, for example PrP-interacting proteins that may be selectively expressed or functionally more critical in some cell types than others.
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Many of the more critical and functionally important regions of rRNA are hotspots for guide-target interactions even though the exact positions of methyl modifications are not always conserved (see Figs. 1 and 2).
Identification and validation of interaction networks and network biomarkers have become more critical and important in the development of disease-specific biomarkers, which are functionally changed during disease development, progression or treatment.
Others are more critical.
Others were more critical.
Mr. Kaplan was more critical.
Lundqvist was more critical.
Others were much more critical.
Other observers are more critical.
People are getting more critical.
Others have been more critical.
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