Sentence examples for functionally loss from inspiring English sources

Cui P, Zhang Y, Cui M, Li Z, Ma G, Wang R, et al. Leukemia cells impair normal hematopoiesis and induce functionally loss of hematopoietic stem cells through immune cells and inflammation.

Functionally, loss of CAR has been suggested to weaken intercellular adhesion, to increase proliferation, and to promote migration as well as invasion of cancer cells (Okegawa et al, 2000, 2001; Bruning and Runnebaum, 2003, 2004; Huang et al, 2005; Wang et al, 2005; Anders et al, 2009a, 2009b).

The present study was thus designed to determine as of whether vestibular sensory cells are needed for otolith growth by applying GM in order to induce a (functionally relevant) loss of these cells.

In summary, we are able to induce and functionally rescue loss of endogenous ATG16L1 expression using ATG16L1 RNAi-resistant expression constructs carrying no epitope tag.

Under LASP-1 knock-down conditions it might be necessary for the maintenance of cellular steady state to upregulate alternative proteins to overcome functionally the loss of LASP-1.

Our observation that ΔN-Bcat expression co-operates functionally with loss-of-function mutations in Apc rather than gain-of-function Kras mutations implies the existence of a minimal threshold level for canonical Wnt/β-catenin signaling to trigger tumor formation (Roose et al., 1999; Samuel et al., 2009; Albuquerque et al., 2010; Buchert et al., 2010; Leedham et al., 2013).

This is functionally important, as loss of 4.1/NuMA interaction results in spindle orientation defects, using two distinct assays.

All three can functionally substitute for loss of their yeast orthologues in S. cerevisiae.

Upregulation of the expression of EHD4, a related family member, in Ehd3 /– GEnCs led us to hypothesize that EHD4 functionally compensates for loss of EHD3.

Although the degree of homology between PTPN13 and PTPN4 or PTPN3 is much less than that between PTPN4 and PTPN3, the possibility that PTPN13 might compensate functionally for the loss of PTPN4 and PTPN3 in T cells existed.

24 Functionally, the significant loss of color vision was associated with higher serum lactate levels.