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BAG-1 may act as a scaffold molecule, to functionally link chaperone function with specific target molecules (Hohfeld et al, 2001; Takayama and Reed, 2001).
Obviously, the above hypotheses, based solely on bioinformatic analysis of transcriptome sequences, need further investigations, in particular ecological experiments and functional protein assays, to functionally link the proposed candidate genes to the observed traits.
To accomplish this we are utilizing novel proteomic, genome engineering, and neural circuit approaches that we have developed to functionally link how perturbations to neural proteomes alter brain function relevant to neurodevelopment and psychiatric disorders.
To functionally link hTRM9L expression to tumourigenicity, we used a gain of function strategy where SW620 and HCT116 cells were engineered to over-express hTRM9L.
Recently in Cell Reports, a team of scientists described an innovative, combinatorial siRNA-based approach to functionally link KRAS effectors and phenotypes in a large panel of cancer cell lines.
The goals of this study were to understand the differences among cultivar-specific OsGLP alleles and to functionally link sequence polymorphisms observed in QTL mapping to differential defense responses.
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Its roles have been ascertained for homeostasis of liver and pancreatic function and have been functionally linked to diabetes [25].
Thus, like the Hedgehog pathway in Drosophila, CDK9 (P-TEFb) and CDK11 appear to be functionally linked for Tat function.
Impairments in LV diastolic function and forearm flow-mediated dilatation were functionally linked in diabetic patients (19).
To test whether the ability of Xrn1 to interact with eIF4G is functionally linked to its role in translation we designed a gain-of-function experiment.
Cossec, J. C. et al. Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes.
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