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This resulted in the discovery of nine mutations in SUFU, which were functionally investigated to determine whether they help drive BCC formation.
In addition, I find that Ctip1, a transcription factor not previously functionally investigated in neocortical development, is a novel control over 1) corticothalamic and callosal projection neuron development and projection neuron migration; and 2) postmitotic area identity acquisition and the formation of sensory maps.
Thus, these clones should be functionally investigated before conclusions can be made regarding their role in cancer.
There also have been large numbers of genes and regulatory factors related to cotton fiber development that have been isolated, functionally investigated by microarray and RT-PCR, and comparatively annotated with Arabidopsis trichome genes [8], [39], [40], [41], [42], [43], [44].
184 of the 200 molecules were functionally investigated, using IPA.
The roles of kinesins in the stramenopile lineage have not been functionally investigated.
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Thus, we set out to characterize protocols to functionally investigate sFlt-1 and sEng from primary trophoblast.
To functionally investigate this aspect endothelial cells with a reduced content of HIPK2 or p53 were generated by transient or stable RNA interference.
Germ cell transplantation results in fertile recipients and is the only available approach to functionally investigate the spermatogonial stem cell biology in mammals and probably in other vertebrates.
In order to develop the in silico and DNA binding analyses and functionally investigate the effects of activated Wnt signaling on Notch pathway genes, nineteen genes in the Notch pathway, known to be important for canonical Notch signaling (Fig. 1 and Table S1), containing putative LEF-1/TCF-sites, were selected for further studies with semi-quantitative RT-PCR.
To functionally investigate mammary progenitor cells, we performed reconstitution experiments into cleared mammary fat pads.
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