The few genes that were downregulated in Plk4 heterozygous MEFs functionally included genes involved in development and metabolism.
America has only been having elections with the protections of the Voting Rights Act that functionally included many African Americans, Native Americans, Mexican Americans, and Asian Americans in our democracy for the first time for 52 years.
It also allows to functionally include interactive external resources in a test.
We examined how structurally and functionally diverse compounds included in the Tox21 chemical space modify core nuclear receptor functions of VDR with respect to VDR heterodimerization with human RXRα, recruitment of coactivator (SRC-1) or corepressor (NCoR), and the ability to initiate/inhibit transactivation of CYP24A1.
These authors focused on sets of functionally related genes included in KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways (Kanehisa et al. 2004) and in GO (gene ontology) terms and compared their ω (d N/d S) values for humans, chimpanzees, rats, and mice.
As shown in Figure 8, functionally diverse enzymes are included in this functional module.
The RCGs determined to be functionally characterized by the majority rule were then used for two purposes: to generate high-confidence functional predictions for the genes included in the functionally characterized RCGs to identify promising new candidate disease genes for OMIM [9] phenotypes of unknown molecular basis, but for which one or more genetic loci have been identified.
Such highly stringent criterion allows the generation of high-confidence functional predictions on the genes included in the functionally characterized RCGs.
Consequently, most of the functionally important genes are included in the resulting core gene sets, especially in the intersection of the two core gene sets.
In the current study, sets of a priori, user-defined functionally related genes were included in the GSEA as well as normalized gene expression data from IFN-alpha treated RPTEC versus control analyses.
