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The results of the functional divergence analysis suggested that caleosin genes should be significantly functionally divergent from each other, especially with respect to the three amino acid residues (70R, 88 L and 106A) identified by both PAML 4 and DIVERGE 2.0 analyses, which were inferred to have played important roles during evolution.
The results of the functional divergence analysis suggested that WRKY genes should be significantly functionally divergent from each other, especially with respect to the four amino acid residues (248E, 275R, 288D and 298E) identified by both PAML 4 and DIVERGE 2.0 analyses, which were inferred to have played important roles during evolution.
The results of type I functional divergence (Table 1) suggested that anoctamin genes should be significantly functionally divergent from each other, owing to the evolutionary rate and/or property differences at some amino acid sites.
The results of the functional divergence analysis (Table 3) suggested that OPR genes should be significantly functionally divergent from each other, owing to the evolutionary rate differences at some amino acid sites.
Although it adopts the LeuT fold, it is functionally divergent from LeuT.
Inspection of the structure suggests that the SANT domain is functionally divergent from the Myb DNA-binding domain [ 36].
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We also used a variety of functionally divergent protein queries from the acid and alkaline phosphatase superfamilies to which dPGM and iPGM respectively belong.
This region is thought to facilitate expansion of the ligand-binding pocket and distinguishes NR1I2 from functionally divergent members of the NRI1 family (Moore et al. 2002).
This is particularly true for metabolic pathways involving the production of unusual fatty acids from functionally divergent Δ12 desaturases (or, FAD2).
Overall, C3 has the least interactions with the other subunits [21] [23] and appears to be the most functionally divergent of the three subunits from homotrimeric PCNA.
Some functionally divergent FAD2 enzymes are multi-functional, such as the bifunctional hydroxylase/desaturase from Lesquerella fendleri[ 21], and tri-functional acetylenase from Crepis alpina, which can also catalyse the formation of both trans and cis double bonds at the Δ12 position of oleic acid [ 22].
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