Where possible, the clusters were annotated functionally by taking the function(s) that were most often annotated to the proteins in the cluster.
While certain copies remain relatively unchanged in the genome for a long time, others diverge functionally by acquiring a new function.
Sequences with no BLAST hits were then searched against NCBI nr database with an E-value threshold of 10−30 and classified functionally by identifying GO terms of molecular function, cellular component, and biological process using the software Blast2GO [ 59].
T cell epitopes within funtional domains would remain conserved over time as viral mutations useful towards immune escape may disrupt the function of the domains and affect viral fitness unless compensated functionally by multiple co-mutations [49], [50].
The above-mentioned defects were reflected functionally by attenuation in IGF1-dependent stimulation of key fibroblast functions, including collagen synthesis and cell proliferation, migration and contraction.
Neutrophil, type of white blood cell (leukocyte) that is characterized histologically by its ability to be stained by neutral dyes and functionally by its role in mediating immune responses against infectious microorganisms.
However, particular social agreement among participants might, for example, invite them to act functionally, by challenging rules and norms.
Using CellNet, we improved B cell to macrophage conversion, transcriptionally and functionally, by knocking down predicted B cell regulators.
We achieved good results esthetically and functionally by putting the incision line at the borders of anatomic structures and repositioning the displaced facial muscles at their anatomic positions.
Analogous experiments are also performed with vacuolar membranes from Saccharomyces cerevisiae, in which subunit c of the V-ATPase is replaced functionally by the Nephrops 16-kDa proteolipid.
We find evidence that the loss of perinuclear actin assembly results in basolateral enhancement of microtubule organization and this is reflected functionally by enhanced nuclear dynamics.
