standards give rise to actual functionality values of phenol in the range 1.49 1.72.
The terminal alkyne is a readily derivatized functionality valued for its diverse applications in material synthesis, pharmaceutical science, and chemical biology.
Correlation and regression analysis confirmed the dependence of green infrastructure elements (corr. r2 = 0.877) as well as travelling costs (corr. r2 = 0.669) to functionality values.
Protection status of the landscape samples proved to be a determining factor because functionality values as well as green infrastructure differed significantly (both with a p-value < 0.05) with the exception of dissecting corridors, stepping stones and travelling costs.
Strikingly, 24 RNMs (11 nonsynonymous and 13 RNA mutations) and 67 SNMs (42 nonsynonymous, 25 RNA mutations) displayed comparable functionality values with those of disease-causing mutations.
Taken together, 24 RNMs and 67 SNMs (nonsynonymous and RNA genes mutations) had comparable functionality values with those of disease-causing mutations (tables 1 and 2 and supplementary table S7, Supplementary Material online).
To identify the group of nodal mutations that possesses comparable functionality values with those of disease-causing mutations, we used resampling simulations with sequential Bonferroni correction for multiple testing (see Materials and Methods).
This approach revealed that for RNMs in RNA genes (N = 67), the upper 20th percentile (13 mutations), lost its statistical significance and therefore had functionality values (RNA mutations functionality scores) comparable with those of disease-causing mutations (supplementary table S6 A, Supplementary Material online).
Additionally, using the resampling simulations analysis, we detected that the upper 11th percentile subset of SNMs in RNA genes (25 mutations), lost its statistical significance making them the RNA genes' SNMs with functionality values most similar to those of disease-causing mutations (supplementary table S6 B, Supplementary Material online).
