Either that or they suggest non-functionality!! Similarly in the 'Implications of the hypothesis' section, para 3: "Specific and conserved alterations (compared to RF1 and RF2) in those parts of RF0 that interact with mRNA suggest that RF0 recognizes something different than normal stop codons".
If so, this implies that STRR mutations in rpsL which reduce ribosome functionality could interact similarly with impaired RpoB activity.
Similarly to functionality, the poorest quality of life was found in PPS positive GAD patients with comorbid MDD (LSM [SD] = 0.3 [0.0], p < 0.0001 vs. GAD+MDD- and control groups, with or without PPS).
However, there is no reason that a library of small molecules presenting different chemical functionalities could not be similarly used to expose other types of cryptic binding sites.
Similarly, more acidic functionality of compound is less effective for inhibition.
"Why do I have three apps on my phone that effectively do the same thing?" Inbox takes some of its messaging cues from email management app Mailbox, with the mission of applying a similarly elegant management functionality across the messaging board — not just to email, but to SMS and OTT messaging.
The functionality of gpD derivatives was similarly reflected in phage sizing of undecorated phage.
Based on theoretical design, series of 2-azetidinones (12 17) and 4- alkoxy carbonyl-2-azetidinones (18–21) bearing various carbonyl (ester, thiolester, amide) and thiocarbonyl (thioamide) functionalities at position N1 were similarly prepared.
Similarly, when modeling the functionality of the urban forest, models must capture this spatial heterogeneity for inter-city comparisons.
It is tantalizing to speculate that the processing of one or more introns in specific genes that have a critical role in motor neuron biology might be similarly affected by reduced functionality of the U12-dependent spliceosome in SMA.
