However, because a gene can have multiple functions, such a single network may be insufficient to represent all the co-functionality relationships between genes.
The proposed method takes as input a combined network produced by an existing network integration algorithm, and reconstructs this network to better represent the co-functionality relationships between gene pairs.
Our identification of domain genetic interactions helps understand how the domains contribute to functionality defined by the SLGIs, and then help elucidate the functional relationships between proteins at domain level from their genetic interactions.
In such a network, each edge is usually assigned a weight representing the strength of the co-functionality relationship between the gene pair.
Although genetic interaction analysis provides a promising method to understand the functional relationship between proteins [ 6], we cannot tell the contributions of different domains to certain functionality of multidomain proteins based on their genetic interactions.
The reference model defines entities for key functionality and relationships between them.
Since 2004 public cheminformatic databases and their collective functionality for exploring relationships between compounds, protein sequences, literature and assay data have advanced dramatically.
The current version, CGAS version 1, provides functionality for viewing similarity relationships between user's sequences, including a multiple dot plot between sequences with their annotation information.
Many of these functionalities are determined by cheese structure, requiring an appropriate understanding of the relationships between structure and functionality to design bespoke functionalities.
It is important to better understand the relationships between product functionality and processing parameters so that optimal processes can be designed to produce ingredients with maximum functionality and bioavailability.
In order to assure the functionality of these surfaces, the relationships between the microstructure designs and the manufacturing processes have to be understood.
