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Since significant functionality of the toolkit is implemented as external Tcl script function snippets, and future enhancements will probably preferably be coded in Python without providing also a Tcl port, providing automatic and fully transparent access to language-mismatched components has been an important and rather peculiar design goal.
Based on Toolkit user feedback, we expect to continue to update the functionality of the Toolkit.
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With Cinfony, all of the core functionality of the toolkits can be accessed with the same interface.
The modular design of the toolkit makes it straightforward to add additional functionality to the toolkit, as illustrated by our implementation of novel tools for generation of draft metabolic reconstructions from a curated reference network.
The combination of this general concept with the extensive scripting functionality of the Cactvs Chemoinformatics toolkit results in a system with capabilities notably different and more flexible than standard pipelining systems.
We demonstrate the navigation, annotation and sharing functionality of the Collaborative Annotation Toolkit for Massive Amounts of Image Data (CATMAID) on a serial section Transmission Electron Microscopy (ssTEM) dataset covering the neuropile of one half of the first instar larval brain of Drosophila melanogaster.
The fingerprinting functionalities of the Indigo Toolkit (http://lifescience.opensource.epam.com/indigo) are tree based.
Subsequently, we realised that the resulting API could be considered a generic API for wrapping the core functionality of any cheminformatics toolkit.
The paper describes the architecture of the toolkit, and its core functionalities, as well as its potential evolutions.
The API is designed to make it easy to carry out many of the common tasks in cheminformatics, and covers the core functionality shared by all of the toolkits.
What is the reach of the Toolkit?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com