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In conclusion, given the therapeutic efficacy of triptans, investigating the functionality of the serotonergic system in the migraine brain remains on the agenda to illuminate disease pathomechanisms and new lines of treatment to enable a superior understanding of the disease process that will further aid in the diagnosis, treatment and management of migraine and headache related disorders.
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The diffuse projection targets of the serotonergic system have led to many theories about its function.
Second, the disturbances of serotonergic function in BN may not be found in SERTs, but instead in other parts of the serotonergic system.
Barreiro-Iglesias, A. "Evorego": studying regeneration to understand evolution, the case of the serotonergic system.
Since both aggression-related traits and serotonergic activity are partially heritable and correlate inversely, variations in genes of the serotonergic system might then, to some extent, account for variations in aggression-related behavior.
Savli, M. et al. Normative database of the serotonergic system in healthy subjects using multi-tracer PET.
This study was designed to assess the effects of prenatal cocaine exposure on the development of the serotonergic system.
The first finding does not support preclinical data suggesting an influence of relative sparing of the serotonergic system.
These findings may provide more evidence for the involvement of the serotonergic system in the brain in exessive drinking of rewarding substances.
There are also effects from other parts of the serotonergic system on the 5-HT1A receptor.
24 Future clinical trials with other anti-serotonergic drugs are necessary to define the role of the serotonergic system in the development of cancer cachexia.
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