In this study, the expression and functionality of the transient receptor potential melastatin 4 protein (TRPM4), an ion channel that controls Ca2 + entry into cells, was examined in the zebrafish embryo and adult.
In this study, we performed viral gene transduction of proteasome activator (PA) subunits (α, β, γ for PA28 and S5a and p58 for PA700) to HD patients' and control fibroblasts and to control and HD model striatal neurons, to determine the functionality of the UPS and potential therapeutics for this disease.
Because there has been no laboratory evaluation of the biologic function of COX-2.8473 polymorphism, additional studies to examine the functionality of the polymorphism and the potential interactions with various inflammation-related genes are warranted.
This example shows that the epigenetic profiles gathered in cisMEP can help researchers assess the prediction confidence of the deposited potential CRMs, deduce the potential functionality of the computationally identified CRMs and possibly establish the transcriptional regulation mechanism hypotheses of these potential CRMs.
We introduce BayMiR, a new computational method, that predicts the functionality of potential miRNA target sites using the activity level of the miRNAs inferred from genome-wide mRNA expression profiles.
The potential functionality of the ladder is also demonstrated by the radioactive source test.
Moreover, MGMT is an inducible protein [33], [36], [37] and lack of immunoreactivity at time of diagnosis might not reflect the potential functionality of the protein.
We considered whether the +139 SNP might alter the secondary structure, and hence the potential functionality, of the rRNA transcript or of the nc-rRNA.
We further explored the potential functionality of the CNVs that are differentially presented between L63 and L72.
Our results in Ma. balthica are congruent with these observations, supporting the potential functionality of the ATP8 protein.
