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To conclude, microdialysis and PET ([18 F]FDOPA and [11C]DTBZ) are sensitive techniques for assessment of the functionality of the dopaminergic system and may both be crucial in furthering our understanding of diseases such as Parkinson's.
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Insights into the function of the dopaminergic system can also be made by microdialysis.
Investigation of the functional activity of the dopaminergic system is increasingly used in the evaluation of tumours of islet cell origin [7 12].
Exposing rats to heavy particles produces alterations in the functioning of dopaminergic neurons and in the behaviors that depend upon the integrity of the dopaminergic system.
Dystonia has commonly been assumed to be a disorder of the dopaminergic system [2].
Another mechanism implicated in the pathophysiology of delirium is overactivity of the dopaminergic system.
The present study demonstrates the sensitivity of the dopaminergic system towards FA.
Several studies indicate that hypersensitivity of the dopaminergic system is implicated in the pathogenesis of migraine [50].
In fact, a PET image of the dopaminergic system was featured on the cover of Nature in 1983 [1].
[18F]FDOPA is a commonly used PET tracer for investigating the activity of the dopaminergic system in neurological disorders.
To do more extensive evaluation of the dopaminergic system, endpoint tissue analyses usually need to be applied.
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