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A significant deviation of an oligo density in the proximity of SSs as compare to background locations is strongly indicative of important functionality of elements related to splicing [ 10, 15, 33].
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All the observed behaviors of the isolated elements suggest functionality of these elements.
Efficient management however entails differentiation between spatial elements and insight into the functionality of these elements.
However, genome-wide study of ISRs is currently difficult, as less is known about ISRs, and their function seems to be highly context dependent, with position within the intron also strongly restricting the functionality of the elements and determining the effect on splicing of the functional ISRs [52], [53], [62].
This concept of multiple functionality of structural elements may find numerous applications, particularly, in the industrial civil engineering field as part of the general trend of multi-disciplinary integration in industrial development.
In addition, three genomic markers (promoters, CGIs and repeats) were included in the CM data profile to understand the functionality of genomic elements and further uncover genome-epigenome interactions.
Epigenetic modifications are linked to the functionality of regulatory elements.
The functionality of these elements is therefore more determined by their structure than by their primary sequence.
While these measurements are more directly assaying functionality of regulatory elements, they are, unfortunately, not a perfect solution.
There is also evidence of the functionality of AuxRE/MYB elements.
In order to verify the functionality of the elements included in pPAC7, the vector was transfected into the cell line SK-BR-3.
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