4) We enhance the functionality of disease-specific searching for relevant proteins and drugs with directionality information.
For relevant drug-protein pairs with directionality information, we use breast cancer as a case study to demonstrate the functionality of disease-specific searching.
2) We will increase the functionality of disease-orientated browsing for relevant proteins and drugs in the CMaps by using disease phenotype trees.
6) We also use breast cancer as a case study to demonstrate the functionality of disease-specific searching for relevant drug-protein pairs with directionality information.
Numerous examples of applications of this functionality to disease systems have been published (11 – 13, 16 – 22 ).
On the whole, the functionality of noncoding disease variants degrades in the order of germline cancer, Mendelian disease, somatic cancer, and complex disease.
Thus, the aforementioned observations rationally lead to the conclusion that the greater the functionality of the disease variant, the greater the level of evolutionary constraint.
We've confirmed things that we already knew, which is valuable, but I would argue that we need to take a pause on teasing out the nuances of the genome to start really understanding more of its functionality in disease, including the non-coding regions of the genome.
The combination of obesity and KOA create a vicious cycle of pain, loss of functionality, and disease progression.
Studies of NK-cell functionality in disease are also significant considering that the novel monoclonal antibodies (mAbs) being researched for MM therapy, such as elotuzumab, daratumumab, XmAb5592, and anti-CD137 mAbs, rely on NK-cell-mediated ADCC.
These recommendations to control pain, maintain functionality and prevent progression of disease include: weight control, correct body posture, thermotherapy, adherence to treatment, physical exercise, rest and orthosis.
