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Chris Mason, Professor of Regenerative Medicine at University College London, said: "Using living cells as therapies has the big advantage in that the functionality of cells is many orders of magnitude greater than that of conventional drugs.
These findings suggest that tryptophan-derived metabolites can affect functionality of cells in the tumor microenvironment.
The functionality of cells was tested by measuring ALP activity of the cells and the results indicated their osteoblastic differentiation.
Combination of these research efforts provides critical information about the functionality of cells and organisms, reveals mechanisms of genetic diseases, enables optimization of diagnostic techniques and therapies, and provides aid in the process of drug discovery.
DNA microarrays [3], in particular, are capable of screening tens or even hundreds of thousands of different gene sequences at the same time, revealing critical information about the functionality of cells, effects of drugs on organisms, and so forth.
These types of systems can enhance functionality of cells by mimicking the tissue architecture complexities when compared to in vitro analysis but at the same time present a more rapid and simple process when compared to in vivo testing procedures.
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This method of cell micropatterning can improve the efficiency and functionality of cell-based devices.
Because of the challenges associated with the procurement of primary hepatocytes and the limitations in functionality of cell lines, the use of stem-cell derived hepatocytes is a seemingly attractive alternative.
This suggests that the increased toxicity of the combination of HP-14 and cisplatin in this cell line is independent of the cell cycle phase or the functionality of cell cycle checkpoints.
Pax6 knockout mice lack α cells, but the functionality of β cells and other endocrine cells is also affected [45].
Areca nuts contain a rich amount of polyphenols that have been shown to modulate the functionality of mast cells and T cells.
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