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Since a full length protein cannot be produced if the 5' end of the mRNA is missing, it is possible that these results could be the due to misprediction of the protein start codon annotation, specific mRNA degradation, or bona fide secondary TSSs whose functionality is unknown.
Although 30 50% of p53 coding sequences in canine OS have polymorphisms [ 33- 35] the effect of these changes on p53 functionality is unknown.
The silkworm is still an enigma in that it has two DNA methyltransferases (DNMT1 and DNMT2) but their functionality is unknown.
Although the "exact" ratio between the values for functionality is unknown, the finding of higher mean promotion values per tooth added by FDP underlines the accuracy of the values assigned.
Of the two VMA homing endonucleases whose functionality is unknown, the one from C. glabrata lacks both these critical aspartic acid residues and the D. hansenii homing endonuclease lacks the proximal aspartic acid.
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For other genes, their exact function is unknown but structural similarities to other proteins indicate some core functionality, such as being a repressor, transporter, or ligase.
Though the proteolytic functionality of ScpI is unknown, it does contain the conserved serine protease catalytic triad of Asp-130, His-193, and Ser-512 [35]; however due to differences in overall protein size these conserved residues fall at slightly different locations in ScpI (Asp-114, His-181, Ser-501) (Fig. S2).
The functionality of ysa2 is unknown.
However, the microstructural architecture of sickle bone and its role in mechanical functionality is largely unknown.
As an example, the minor allele of the rs6511720 polymorphism in LDLR was associated with a reduction of 6.99 mg/dl in total cholesterol levels [ 12] and this variant has been included in the LDL-C gene score proposed by Talmud, however its functionality is still unknown [ 6].
With regard to the immunohistochemistry data, while it was demonstrated that differences did not exist in androgen receptor protein expression between the intacts and castrates, the functionality of these receptors is unknown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com