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With cracking, chapping or the formation of exudative lesions, this functionality is lost.
Together, these results indicate that CREB functionality is lost during the early stages of striatal cell stress and that the repression of CREB-mediated transcription contributes to the pathogenic process.
It has been suggested that ataxin-1 is present in a transcription/RNA processing complex [7], [18] whose functionality is lost upon transcription inhibition.
No functionality is lost, this is just annoying.
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One PAM2L motif is sufficient for function, but if both PAM2L motifs were mutated Upa1 functionality was lost.
General manager Sean Murphy, said: "Over 40% of floor space was lost at one stage and about 70% of our overall functionality was lost.
During these time intervals, less than 10% of receptor functionality was lost at each step (Table 1).
Collectively, these observations lead to the question whether long-term exenatide administration to patients with type 2 diabetes may restore some of the β-cell functionality that is lost as part of the natural history of the disease.
Scoring unipolar growth and secretion of Cts1 revealed consistent results leading to the conclusion that one PAM2L motif is sufficient for function, but if both are mutated functionality of Upa1 is lost.
In addition, much of the (native) functionality of proteins is lost during processing.
If such a voltage is applied, the driver is not able to turn the active element on and the functionality of the converter is lost.
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