Since the functionality of coastal dunes is affected by the specific contiguity among different dune habitat patches, in this paper we propose the use of landscape integrity, expressed by the number and length of boundary types among the aforementioned habitats, as an ecosystem functionality indicator.
Examining the weights of the three formative indicators of the "EMR functional coverage" construct, one finds the "availability of clinical functionalities" indicator to be by far the most determinant (γ = 0.80, p < 0.001).
Further examining the weights of the three indicators that "form" the "extended EMR use" construct, one finds that the "use of clinical functionalities" indicator is by far the most determinant (γ = 0.82, p < 0.001).
We then examined separately their evolutionary selection (purifying or relaxed), mechanism of duplication (e.g., segmental versus tandem duplications), and their expression levels/patterns, which are all potential indicators of functionality and evolutionary history.
In the present study, we decided a priori to use the functional well being scale (FWB) (range: 0 28), the fatigue subscale (FS) (range: 0 52) and the FACT-F Trial Outcome Index (TOI) (range: 0 108) as indicators of functionality.
Most of these retrocopies exhibit yield indicators of functionality, such as 1) they were already reported as transcribed genomic regions; 2) they contain an annotated reference mRNA sequence; 3) they appear to be under purifying selection; and d) they are related to the X chromosome, as some migrate out and others into the X chromosome.
Nevertheless, the observation reported here that lncRNAs of known function do show these signals of selection (reduced diversity and divergence) that are comparable to PC loci suggests that these signals are indeed good indicators of functionality for at least some proportion of noncoding loci.
The paper describes the tool features including: (i) automated calculation of built environment variables; (ii) "sketch planning" functionality; and (iii) suite of indicators including a walkability indicator that estimates the probability that an adult would walk for transport.
The problem statement is related to microeconomic models of dynamic optimization of a company's indicator of functionality development.
Evolutionary conservation of sequence information is considered a good indicator of functionality and is used in microRNA target prediction programs [34] to assign confidence levels.
