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The allyl containing trichloroacetimidate 44 b, which due to the additional alkene functionality capable of competitive palladium coordination is a challenging substrate for this reaction, resulted in (R)- 45 b in 71%% ee.
Over the past decade a number of groups have used various scaffolds to project functionality capable of making multivalent hydrophobic, ion-pairing and metal ligand interactions over a protein surface to achieve high affinity binding.
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This procedure can be easily tailored to provide the nanoferrites with various functionalities capable of further modifications with, e.g., drug molecules.
To overcome this limitation, we designed ketone-based functionalities capable of forming reversible covalent adducts, while displaying high metabolic stability, and imparting improved water solubility to their pendant scaffold.
This suggests that it may be possible to develop analogs that replace the phosphates with noncharged functionalities capable of satisfying the hydrogen bonding requirements.
Thanks to "big data", satellite navigation, GPS-enabled smartphones, social networking and 3D visualisation technology, maps are becoming almost unlimited in their functionality, and capable of incorporating real-time updates.
Our strategy consists of building 2PA chromophores containing the isothiocyanate functionality, −N=C=S, capable of forming a stable linkage with biomolecules containing −NH2 amino groups.
Their size and surface functionality makes them capable of a variety of biomedical functions.
The assistant's voice sounds great, and its functionality is pretty capable.
In the bill Minnesota legislators lay out the requirements: "Any new smart phone manufactured on or after July 1, 2015, sold or purchased in Minnesota must be equipped with preloaded antitheft functionality or be capable of downloading that functionality".
Furthermore, a case study of the Greater Cincinnati area at regional level is performed to test the integrated functionality as a capable tool for urban planning, transportation and environmental analysis.
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