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The species turnover did not imply a functional turnover.
The presence of LOF candidate regions near these transcription factors suggests recent functional turnover at their regulatory regions.
This suggests that the new-lineage specific HCNSs were created during functional turnover and that gaining the new HCNSs did not contribute to the lineage-specific evolution.
These experiments support the role of autophagy in normal developmental processes that occur in the absence or diminished levels of nutrient supply, lending further importance to the need for the functional turnover of amino acids.
Because we defined LOF candidates as regions where phylogenetic and population genetic signatures of purifying selection disagree (phastCons and popCons, respectively), they may be enriched for false positives, especially if functional turnover is a rare event.
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Dalton and Todor (1979) and others lauded a functional view of turnover, arguing that moderate turnover rates bring new ideas and infuse the organization with stagnation-fighting energy from outside.
Interestingly, phospho-Zfra undergoes rapid de-phosphorylation and degradation, suggesting that Zfra may affect the functional activation and turnover of its binding proteins.
If natural selection affects the persistence of functional compensation, the turnover rate is likely to be slower in genes with functional compensation to more severe phenotypes than genes with functional compensation to less severe phenotypes.
Despite the ease of modern gene editing tools, analyses of overexpressed and/or tagged proteins frequently fail to recapitulate the endogenous protein characteristics, such as expression level, turnover, functional epitope availability and, as a consequence, their localization and dynamics (Huh et al., 2003; Swulius and Jensen, 2012; Khmelinskii et al., 2012).
The slow speed of turnover of functional visual pigment molecules also helps to extend the eye's ability to respond to high light levels.
Three sets of 120 phytosociological relevés, sampled in 1987, 1999 and 2014, have been compared to assess: (1) nestedness vs spatial turnover, (2) functional diversity and (3) the importance of vegetation dynamics on green roof performance and design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com