Sentence examples for functional trail from inspiring English sources

In that regard, we have shown that high levels of PLAU mRNA are observed in breast tumors showing Her2+, PgR− and/or p53 mutant phenotypes and that such levels correlate with the apoptotic response of breast cancer cells to TRAIL, suggesting that this type of cancer may express a functional TRAIL cascade.

These data indicate that the presence of a functional TRAIL receptor apoptosis pathway can regulate chemosensitivity through tumor cell extrinsic mechanisms.

The expression levels of the functional TRAIL and FASL receptors were examined at the RNA level by RT PCR.

These results show that S. typhimurium can express and secrete a functional TRAIL protein, with control of expression by genotoxic damage from a small dose of radiation.

We show here that high mRNA levels of PLAU, which encodes urokinase plasminogen activator (uPA), are characteristic of cancer cells with functional TRAIL signaling.

In order to minimize loss of functional TRAIL activity, we have compared two different biotinylation strategies that react at different functional groups in the protein.

It is therefore of major importance to identify tumor-related features of those cancer cells that have maintained a functional TRAIL-apoptotic pathway and to assess the relative impact of the associated apoptogenic and survival/proliferative functions of this cascade.

By following such an approach, we identified PLAU mRNA as a molecule whose high expression is characteristic of cancer cells with a functional TRAIL-apoptotic cascade and whose level has a direct correlation with the sensitivity of cancer cells to trigger TRAIL-induced apoptosis.

Table 1 reports descriptive statistics for descriptive variables (age, baseline EQ-5D HSUV, group, education, average waist girth, functional comorbidity index, trail making part A, trail making part B, Digits Forward, MMSE and TUG) and our outcome of interest (QALYs).

In melanoma, we had previously shown functional activity of TRAIL receptors; however, some melanoma cell lines showed permanent TRAIL resistance and others developed inducible resistance upon TRAIL treatment.

To address this question, we constructed isogenic tumor cell lines that are functional for both TRAIL and FasL signaling, inhibited for both or inhibited for just TRAIL signaling.