Furthermore, inhibitor intervention at early or late stages within the amyloid aggregation pathway is shown to correlate with the ability of these functional groups to recognize and bind amyloid species that appear either early or late within the aggregation pathway.
All these data revealed that BmKKx2 mainly used Tyr11, Lys18, Arg20 and Lys23 as the functional residues to recognize hERG channel, which was similar to the binding surface of toxin BeKm-1.
DAVID is a publically available database (http://david.abcc.ncifcrf.gov) that offers a comprehensive set of functional annotation tools to recognize biological meaning behind list from high through put experiments.
The Onto-Express module helps to recognize functional profiles (using gene ontology terms) for the categories: biochemical function; biological process; cellular role; cellular component; molecular function, and chromosome location [ 20].
Therefore global correlation measures taken across diverse experimental conditions will be significantly reduced, and thus undermine its ability to recognize functional related genes.
Structural similarity methods may employ chemical, physical, energetic or geometric criteria to recognize functional environments [ 8- 10].
Additionally, it is possible to improve the ability of FEATURE to recognize functional sites, for example, by exploring the conformational space of the molecules in question.
Our goal in this study was to recognize functional classes of genes and individual candidates involved in the mechanisms underlying susceptibility to the opioid actions.
The Orc/Cdc6 proteins, experimentally proven functional in their ability to recognize replication origins in other archaea (Pyrococcus abyssi[ 4], Sulfolobus solfataricus[ 5, 6], Aeropyrum pernix[ 7, 8]), were also included in this phylogenetic analysis.
With this approach, RBHs are interpreted as potential one-to-one orthologs whereas co-orthologs are ignored; this way we are able to look for GO terms overrepresented in the set of sequences that remain unpaired (including possible gene duplications and alternative transcripts) as a means to recognize functional categories that are particularly frequent in the annotation of cassava transcripts.
In previous work, structure-based functional site descriptors, fuzzy functional forms (FFFs), were developed to recognize structurally conserved active sites in proteins.
