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In particular, HS-binding CPPs are suitable drug carriers for in vivo application in delivery of functional therapeutics.
Nevertheless, it has the potential to be explored as prospective functional therapeutics to manage IBDs by establishing its clinical efficacy in well-designed double-blind placebo-controlled human trials.
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Here, functional scaffolds delivering therapeutics are reviewed in terms of their controlled release and healing capabilities.
The roles of carbohydrates in human health and diseases are raising topics to develop functional foods and therapeutics.
To date, the major emphases for the applications of RNAi have been functional genomics and therapeutics.
The inhibition of protein interactions, such as receptor-ligand interactions or the interplay during pathogen infections, is one main functional principle of therapeutics to influence biologically relevant processes.
Small interfering RNAs (siRNAs) have become the most powerful and widely used gene silencing reagents for reverse functional genomics and molecular therapeutics.
Wang et al. reviewed the complex analytical tools that have been developed and optimized for the molecular and functional characterization of antibody therapeutics (Wang et al., 2017a).
The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of genes.
However, an increase in expression of Noggin at the mRNA level with cyclic pressurization suggests that these bioactive molecules produced by NCs could also be functional as symptom-modifying therapeutics for treatment of painful IVDs.
Positively induced pathways comprised those linked to cellular assembly and organization and cellular response to therapeutics, while functional pathways that were subject to down-regulation in topotecan-treated OC spheroids were associated with cell-to-cell signaling and interaction, metabolism, immune response, protein trafficking and molecular transport.
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