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However, no eukaryotic nuclear gene that would lack a functional termination codon specified directly by the gene sequence has been found so far.
Other studies involving the physical or functional termination of Survivin by various molecular entities demonstrated spontaneous sensitization to caspase-dependent apoptosis in vitro and also in animal models.
The conservation pattern is very similar between S. barkhanus and S. salmonicida, with a strong positional correlation between the termination codon and the beginning of the polyA-tail, but only weak conservation outside the UGA codon, the only functional termination codon in Spironucleus [ 17].
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forms of Sup35p found in a [PSI+] cell may still be functional in termination.
This conversion has two functional implications the termination of DAG signalling and the initiation of PA signalling.
Thus, one signaling cycle or constant action of NF-κB from LMB or CHX, respectively, induced opposite functional consequences: premature termination or uncontrolled accumulation of target gene transcripts.
We therefore deduce that although the MuRVY element is degenerate and does not encode a functional retrovirus, its transcriptional termination site has remained functional and become co-opted to form the transcriptional termination site for Orly forward transcripts.
Such analyses can provide a direct link between protein sequence and structure as well as insight into functional aspects of translation termination and mRNA decay.
In addition, we identified 90 additional cases where the gene sequence specified potentially functional UAG or UGA termination codons, which were transformed into the UAA codon by polyadenylation (supplementary fig. S1 B, Supplementary Material online).
Our findings highlight the importance of further investigation of the relationship between this and attrition, and interventions to prevent and/or break a cycle of functional decline and premature termination of treatment.
Specific functional interactions include the termination of brain neuropeptides, such as enkephalins and substance P, at peptidergic synapses [ 72], and the degradation of the hypotension-inducing atrial natriuretic peptide (ANP) [ 71].
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