Exact(1)
The delivery of antibody mimics to the cytosol of cells as indicated by DTA activity and western blotting, together with the observation of functional tandem monobody binder to the oncoprotein Bcr-Abl and affibody binder to hRaf-1, supports our belief that the PA-mediated protein delivery system (designed by nature) will significantly expand the biomolecular delivery toolbox.
Similar(59)
Main Outcome Measures: Unipedal stance time, functional reach, tandem stance time, and score on the activities-specific balance and confidence (ABC) scale.
Only the intervention group showed a significant improvement in single-leg stance time, functional reach, tandem stance time, and activities-specific balance and confidence (ABC) scores.
As functional trinucleotide tandem repeats that vary in humans have been shown to be also variable in chimpanzee [ 30], it is likely that all these genes present variability in both species.
Hence, given the abundance of sequence variation evident here, functional differentiation of tandem duplicates may be commonplace, suggesting a subtle functionality within tandem arrays not yet appreciated in T. brucei.
In order to obtain the protein functional classification of tandem duplicated genes, InterPro was employed to provide functional analysis of tandem duplicated genes by classifying them into different families and predicting conserved domains and important sites (39).
For instance, a detailed functional analysis of tandem duplicated ABC genes in the worm has revealed differential function of the duplicates, with expression being highly tissue or stage specific [ 67].
Such tandem functional operation by DNA polymerase, lambda exonuclease and DNAzyme endows the developed biosensor with a high sensitivity and also a high confidence.
This study examined if a common functional variable number tandem repeat polymorphism in the 3' untranslated region of the DAT gene (SLC6A3) influences amygdala function during the processing of aversive emotional stimuli.
We generated comprehensive functional annotation of tandem duplicated genes.
Assessing microbial functional responses in tandem with additional human genetic risk variants may help to better identify their functional consequences in vivo.
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