Sentence examples for functional synergy between from inspiring English sources

We conjugated the tumor suppressor antimiR-222 to each aptamer demonstrating: 1) effective and selective delivery to receptor-expressing tumor cells, 2) increased expression of miR-222 target mRNAs, and 3) functional synergy between the kinase inhibitory aptamer and the antimiR antagonizing functions.

Finally, the combinatorial mutants also reveal functional synergy between semi- and nonconserved positions.

Conversely, the medulloblastoma cell line ONS76 exhibits neither MYC amplification nor a detectable PVT1-MYC fusion gene, and knockdown of miR-1204 had no effect in this line (Fig. 6c). Figure 6: Functional synergy between miR-1204 and MYC secondary to PVT1-MYC fusion.

Transactivation by HNF-4 thus appears to result from functional synergy between the NHRRE binding HNF-4 and distal DNA elements containing intestinal-specific DNA binding activities.

To understand the molecular basis for the dramatic functional synergy between transcription factors that bind to the minimal T-cell receptor alpha enhancer (Ealpha), we analyzed enhancer occupancy in thymocytes of transgenic mice in vivo by genomic footprinting.

This assay revealed for the first time that in the case of two composite elements a functional synergy between CTCF and the unliganded TR confers enhancer blocking.

Future studies will aim to define the high-resolution structure of the SYCP3 fibre, explore the effect of SYCP2, cohesin and condensin on SYCP3 assembly, and investigate potential molecular mechanisms underpinning functional synergies between SYCP3 and double-strand break induction.

One reported example of functional synergy is between phosphorylation of the SIN residue H3(T118) and the SWI/SNF remodeler: each destabilizes the nucleosome on its own, but together they are much more disruptive.

Importantly, co-occupancy produces functional synergy in the absence of direct physical interaction between TFs and is missed in analyses that depend on protein-protein interactions.

Thus, we wanted to estimate potential associations between T3Es, which may provide clues on potential functional synergies or redundancies between pairs of T3Es.

In addition, cross-impact analysis can provide insights about functional synergies among sub-technologies.