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We conjugated the tumor suppressor antimiR-222 to each aptamer demonstrating: 1) effective and selective delivery to receptor-expressing tumor cells, 2) increased expression of miR-222 target mRNAs, and 3) functional synergy between the kinase inhibitory aptamer and the antimiR antagonizing functions.
Finally, the combinatorial mutants also reveal functional synergy between semi- and nonconserved positions.
This assay revealed for the first time that in the case of two composite elements a functional synergy between CTCF and the unliganded TR confers enhancer blocking.
Interestingly, although Grb2 appears to interact with PRR1 and PRR2, our data suggest that only the interaction with PRR2 is absolutely required for functional synergy between the two (Fig. 2).
We also evaluated functional synergy between transcriptomics and proteomics results.
Interestingly, expressing both MeCP2 and CREB1, but not MeCP2 alone, enhances transcription of the MeCP2 target genes showing functional synergy.
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They were a mixed bag, but, with Lula, a pragmatist, at the helm in Brazil, there was a sense of promise that somehow socialism and capitalism could find functional synergies, and coexist in the region.
In addition, cross-impact analysis can provide insights about functional synergies among sub-technologies.
It promotes functional synergies (win win situations) as well as trade-offs among various benefits resulting from ecosystem processes.
In this phase, over-assignment of parts to the cells, machine purchasing cost, and loss of functional synergies are attempted to be minimized.
Thus, we wanted to estimate potential associations between T3Es, which may provide clues on potential functional synergies or redundancies between pairs of T3Es.
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