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These results suggest that the functional synergism of HBx and C/EBPα by interaction of both proteins can induce the SOCS3 expression.
We then assessed whether the functional synergism between TLR and MHC class II molecules might be paralleled by their physical interaction.
To further support the functional synergism between Nutlin and 17AAG in vivo, we monitored its antitumor effects on tumor xenografts.
It plays a crucial role in the functional synergism between Pax8 and NKX2.1 in thyroid specific gene expression [ 20, 30].
Moreover, a functional synergism of SP1 and the nuclear factor Y (ECAT) in transcriptional stimulation of the rat pyruvate kinase M (PKM) gene could recently be demonstrated [ 25].
Substantial evidence is accumulating to indicate functional synergism between the nonreceptor tyrosine kinase c-Src and members of the EGF receptor family in promoting breast cancer progression.
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Further analysis may indeed uncover how these factors converge on critical target genes and explain functional redundancy or synergism.
However, functional interaction and synergism between ABA and ethylene during the beginning of grape berry ripening (véraison) has been found recently.
Because of the significant functional coupling and/or synergism that can exist between cPLA2 and sPLA2 in various cells [ 3, 13, 33- 35], sPLA2 could conceivably be involved in chondrocyte destruction in RA by playing a role in bone resorption through crosstalk with cPLA2.
Consequently, because of the extensive CS diversification and the presence of various chitinous structures, lophotrochozoans may be the most interesting taxon to study CS regulatory mechanisms, synergism, and functional divergence in metazoans.
The co-administration of the antioxidant N-acetyl L-cysteine blocked the increased reactive oxygen species generation and apoptosis observed in the combination setting compared with control or single-agent treatments, suggesting that oxidative injury plays a functional role in the synergism.
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