Sentence examples for functional switches from inspiring English sources

Changes in splicing patterns can affect biological processes by many different mechanisms, including gain-of-function or functional switches, altered cellular localization, dominant negative effect, changes in protein/mRNA stability.

Finally, the different groups were also checked for the presence of proteins identified as containing ELMs involved in functional switches, the status of which ultimately affects the function of the ELM-containing protein (collected in the switchELM database19).

This design is expected to be applicable to other proteins to convert them into functional switches.

These libraries are then subjected to selections and/or screens to identify those rare gene fusions that encode functional switches.

By studying with the single molecule force spectroscopy (SMFS) methodology the mechanical behaviour of single biomolecules, we are learning how mechanical forces like those present in the extracellular space modify the conformation of proteins, possibly leading to functional switches.

When different types of functional switches are considered, the candidates are enriched in proteins containing binary switch motifs (with an ON/OFF state) modulated by allosteric effects (1.6-fold, P-value=4.85e-2), compared with Multi-NCs and hubs, which show no enrichment.

The functions of the known genes detected in our analyses are consistent with the functional switch of DCs between the steady and activated states.

Taken together, these findings suggest that p27kip1 acquires additional functions in cytoskeletal regulation and neuronal migration during growth arrest and that this functional switch is mediated at least in part by Cdk5 (Fig. 5).

It would be interesting to further investigate whether this "functional switch" occurred in duplicated RNase4 genes, which would require studying the physiological functions of the RNase4 genes in the little brown bat and other related bat species.

Mahara, S. et al. HIFI-alpha activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.

Systematic disruption of this system shows that a functional switch requires the presence of several, rarely occupied, intermediate states that separate the 'on' and 'off' states.