Sentence examples for functional surrogate from inspiring English sources

AID combines two critical functions of antibodies, class switching and affinity maturation and may serve as a functional surrogate of protection.

Electrical endothelial resistance was measured as a functional surrogate marker of endothelial damage.

The mollusk acetylcholine binding protein (AChBP), a structural and functional surrogate of the human nicotinic acetylcholine receptor (AChR) ligand-binding domain [ 8- 11], is one of countless examples that illustrate the importance of accounting for these atomistic motions.

In CHO cells expressing these mutant proteins, an increase in non-linear capacitance, the widely accepted functional surrogate for electromotility, was absent with Y520Q and markedly diminished with Y667Q.

We therefore wondered whether the antigen-binding molecular signature influenced by aspartic acid in pocket 1, and lysine in pocket 4 Asp84-Lys699) of DPβ1, rather than the motif determined by pocket 1, 4, 6 and 9 might provide a more specific functional surrogate of outcome in UKALL XI.

The two authors also emphasized the importance of a sound rationale for interpreting individual measures as functional surrogates of macro-constructs.

The knowledge base enables use of haemodynamic and metabolic signals in brain imaging and spectroscopic studies as functional surrogates.

We examined the dose escalating effect of gefitinib treatment on EGFR and MAPK phosphorylation after ligand stimulation since these phosphorylated proteins are functional surrogates for an activated HER signaling pathway (Albanell et al, 2001).

In this context, functional imaging surrogate parameters seem to be an improvement and may have potential to enhance traditional imaging evaluation.

In particular, PS is considered a functional CT surrogate marker of neoplastic angiogenesis, focusing on the interest of the use of CTp in oncologic imaging [ 2].

TA modules that are active and functional in surrogate cloning hosts may also generate bias in metagenomic libraries by enhancing stabilisation of constructs (such as metagenomic clones) harbouring them.