Exact(4)
No significant differences in either of the tissues/model systems were demonstrated for these genes, not providing any functional support from expression studies for the network C genes, also no enrichment of T1D associated SNPs was observed in this network.
One reasonable approach is to prioritize SNPs with prior functional support from increasingly available omics studies.
Five of the salmon Z lineage genes have functional support from gene expression assays while ssZBAa and ss ZDAb may be pseudogenes (Additional file 3: Text S2).
We found that the use of our pyramid approach, which prioritizes SNPs with prior functional support from studies of high-throughput molecular phenotypes (i.e., both mRNA and miRNA expression), substantially improved power to detect significant associations with platinum sensitivity.
Similar(55)
Functional support for targeted secretion was obtained from isolated beta cells, which showed polarised calcium responses [ 2], and, using microelectrode-detection, polarised insulin secretion [ 3].
Therefore, while positional enrichment of motif location relative to start codons can be used as functional support when the motif is derived from genes of multiple functions, a high-degree of positional enrichment can also be used to identify a motif as a potential artifact if the genes come from a highly-duplicated gene family as is the case for antigenic variation genes.
Turning to the functional dimension of social support, two functional support variables were found to be significantly associated with parental morale: receiving emotional support from at least one child and baseline amount of support received from children.
Two thirds (n=38 / 63%) of respondents reported getting functional and emotional support from family and friends, but wished for improved understanding/compassion from others and more efficacious medications.
For example, persons who are experiencing cognitive loss or decline of functional ability may receive support from home care agencies, supportive housing, rehabilitation services, or nursing homes.
Given that healthy Betz cells require support from functional oligodendrocytes, it is further unlikely that the lack of oligodendrocytic pathology was due to a loss of oligodendroglia, a suggestion supported by our finding of a similar density of oligodendrocytes in white matter tracts of ALS and controls (Additional file 3: Figure S3).
The argument for the IBM is the simple fact that rearrangements that would break functional regions of the genome are selected against, which has since received some support from a functional analysis of vertebrate genomes [ 30].
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