Sentence examples for functional substitution from inspiring English sources

However, given that the N-terminal regions of harmonin and Cip98 are not functionally interchangeable (Pan et al., 2009), any functional substitution of harmonin by Cip98 in the photoreceptor must not rely on protein interactions in the N-terminal region.

In summary, skin homeostasis and also tissue remodelling processes like embryonic skin development and cutaneous wound healing are independent of MMP13 either owing to MMP13 dispensability or owing to functional substitution by other collagenolytic proteinases such as MMP8.

As for where to look, I'm interested in what people are trying to do and failing at, what gets used in October but disappears by January, what tool evolves into what tool, what kinds of functional substitution happen, what great ideas go nowhere, which tools used by one side baffle the other, etc.

As the G6pd2 expression profile is similar in B6 and Spr, it should be capable of functional substitution of G6pdx in both species.

In B6, the expression profiles of G6pdx and G6pd2 conform to functional substitution of the X-chromosomal parental gene by its autosomal counterpart: G6pdx is expressed premeiotically, whereas G6pd2 is expressed in spermatids.

Among the sites that are not within scanD-7 or scanD-8, EBS3 is perfectly conserved among species whereas EBS4 is conserved with a functional substitution (GGAA instead of GGAT) in chicken, stikleback, fugu, and medeka or a one-base shift in marmoset (Figure S6).

We have genotyped cases and controls for a polymorphic (TA n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89.

A variety of functional substitutions were also introduced to maximize the binding interactions.

Most users are interested in the part of the signal that results from structural or functional substitutions, but in poorly curated datasets this signal can be masked by the phylogenetic signal [5].

There are three possible explanations for the recent excessive accumulation of functional substitutions in our species: (1) adaptive shifts and positive selection, (2) insufficient time for purifying selection or (3) relaxation of selective constraints.

Each binds K-turn-containing RNA, and some functional substitutions are possible [49].