The following patient characteristics were entered into the analysis: age, sex, living situation of the patient (alone or not), whether the patient had an additional diagnosis (none versus at least one), functional status, and starting point of case management (early or later in disease trajectory).
The building has a logic to it: functional sections are the starting point, but they are placed so that the spaces between them are large enough and spectacular enough to produce powerful architectural effects.
A second in silico comparison was made using KEGG [ 12] functional annotations as a starting point.
These hypothesized functions may serve as a starting point for further functional studies in the respective organs.
Inspecting genome databases and expression arrays (of an enzyme, transporter, receptor or ligand) without their integrative functional knowledge with respect to various forms of arthritis will be a starting point for functional genomics in this area.
Nonetheless, we can further narrow our criteria for site prediction expecting that in the case of the Epd data, sites predicted with a more stringent PP (i.e., > 0.9) be in fact functional divergence-related sites that can serve as a discrete starting point for future functional characterization of the Epd proteins.
At this point, these analyses comprise a standard methodology that we routinely apply as part of larger projects, often as a starting point for functional studies in the wetlab or as a part of a Mendelian randomization study.
We suggest, when analyzing proteins in low throughput, to use remotely conserved HMMerThread domains as a starting point for functional prediction and – especially when looking at remotely conserved domains with very low sequence similarity – to proceed with an independent verification step.
However, these studies offer at best only a starting point for functional studies focused on a smaller subset of genes.
Nevertheless, our current functional model provides an excellent starting point for deciphering the underlying physical interactions with DNA binding profiles or protein protein interactions.
These data can also be used for phylogenetic, population genetic, and functional genomic applications, provide a starting point for identification of genomic regulatory sequences, and assist with assembly of hemipteran genomes sequenced in the future.
