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The inactive and active states of kinases share similar structural features due to the functional similarity between kinases and therefore provide limited selectivity.
The proposed function-based approach (FBA) utilizes GO annotations to measure the functional similarity between pathways.
In addition, the close structural and functional similarity between EC and 15d-PGJ2 suggested both molecules induced these effects by activating similar signaling pathways.
Following landscape change, species invasions and extinctions may lead to biotic homogenisation, resulting in increased taxonomic and functional similarity between previously distinct biotas.
There is chemical and functional similarity between LMW molecules synthesized by host eukaryotic cells, indigenous and probiotic microorganisms and some micronutrients.
Despite the overall functional similarity between Bnip3 and NIX, many studies have also revealed their differences.
In our study, we employed a slightly different definition of functional similarity between terms.
Functional similarity between two proteins is determined by using a semantic similarity measure proposed by Couto et al. [34].
In order to benchmark CODA it was therefore necessary to determine the functional similarity between an arbitrary pair of proteins.
Given the functional similarity between Agrp and Npy, the extent to which their regulatory mechanisms overlap may define distinct roles for these neuropeptides in energy homeostasis.
In order to determine functional similarity between proteins, many approaches try to identify the sub-sequences of the proteins that may contribute to their function.
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