Basic science: Humans and nematodes (worms) are 70percentt genetically similar, but shared DNA does not equate to functional similarity.
The functional similarity of a group of genes is then given by the average pairwise functional similarity.
Nagele, V. et al. Neisseria meningitidis adhesin NadA targets beta1 integrins: functional similarity to Yersinia invasin.
To define functional similarity of two genes we use Simpson and Jaccard similarity coefficients (see Methods).
These probabilities reflect biases towards infrequent association implying functional dissimilarity or, conversely, frequent association indicating functional similarity.
Pax-6 5a) Pax-6 5anctional showsarity to the Drosophila eyg, which also lacks the PD required functionalction30.
Functional similarity of two genes is defined as the similarity between the sets of their GO annotations37.
Hence, the results of Fig. 6A rule out Hypothesis B. Figure 6: Functional similarity of tissue-specific disease genes.
Most methods used sequence alignments with an underlying hypothesis that sequence similarity is correlated with functional similarity.
The associated regions functional similarity for primary sensation suggests a role for VSTs in sensory experience during sleep.
Alternatively, the observed increase in the functional similarity of disease genes could occur solely due to the fact that tissue-specific genes are functionally more uniform (Hypothesis B).
