This approach has the benefit of not being dependent on orthology relationships (like some of the analyses performed above), and can identify conserved functional signatures if the same gene function is carried out by different paralogs in the two species.
We discuss three examples of domains where functional signatures are only partially conserved and show that function annotation is 'non-trivial' even when all methods concur on detection of distant relationships.
Moreover, several proteomic and functional signatures were biofluid-specific.
In this review, the key functional signatures of the intervertebral disc are discussed and used to propose a series of native tissue benchmarks to guide the development of engineered replacement tissues.
Strikingly, the two assigned gene sets have very different functional signatures.
Some methods compare divergent, aligned proteins to spot discriminating residues that suggest functional signatures in sequences (EFICAz2) [20] or in structures (FLORA) [23].
To determine whether these endodermal subpopulations were indeed already fated toward specific endodermal fates, we sought to identify functional signatures using GO [30].
Moreover, phenotypic and functional signatures of CD8 T-cells could also be used to monitor individuals latently infected with Mtb at a high risk of progression to active tuberculosis, such as those with HIV coinfection or on anti-TNF therapy.
These results, together with those reported in this paper, suggest distinct T-cell functional signatures between subjects which control Mtb infection (LTBI individuals) and those who do not (active TB disease).
The fact that the pollinator fauna varies geographically in this system gives rise to geographic mosaics of network patterns, with distinct functional signatures on plant performance through fitness effects, as revealed by our results.
Given that all 19 patients responded well to anti-TB treatment these dynamic MTB-specific T cell functional signatures suggest a biomarker of treatment response and decreasing mycobacterial load.
