Exact(2)
In this study, we modeled synapse elimination in neuronal circuits using the modified Izhikevich's model with functional shifting of GABAergic transmission.
Taken together, sequence variations, functional shifting and switching in mature miRNA sequences, described in this study, diversify significantly miRNA regulatory capacity in A. gambiae.
Similar(58)
More specifically, orthologs are more likely to share the same function while paralogs can undergo functional shifts.
In both these cases, the sites under positive selection were not involved in a functional shift as the lipase function was conserved.
The metabolic cost and functional shift hypotheses regard the architecture underlying immune functionality fundamentally different.
These signals are essential for our understanding of functionally important residues in a protein sequence and protein functional shift.
Based on site-directed mutagenesis data, we established that three sites under positive selection were involved in the functional shift leading to the type-A feruloyl esterase function.
Further modification for this new semiflight function (secondary adaptation) would eventually render the structure suitable for yet another functional shift, namely to weak powered flight (exaptation again), with further modifications leading to new improvements specific to flight (secondary adaptation again).
It showed that functional shift can occur in differential tissue expression rather than in biochemical function of the protein.
In using this measure (or other measures of selection) to predict functional shifts, one is making the assumption that each protein-coding gene functions independently.
But he is unduly alarmist when it comes to functional shift.
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