In both these cases, the sites under positive selection were not involved in a functional shift as the lipase function was conserved.
The metabolic cost and functional shift hypotheses regard the architecture underlying immune functionality fundamentally different.
These signals are essential for our understanding of functionally important residues in a protein sequence and protein functional shift.
Based on site-directed mutagenesis data, we established that three sites under positive selection were involved in the functional shift leading to the type-A feruloyl esterase function.
Further modification for this new semiflight function (secondary adaptation) would eventually render the structure suitable for yet another functional shift, namely to weak powered flight (exaptation again), with further modifications leading to new improvements specific to flight (secondary adaptation again).
It showed that functional shift can occur in differential tissue expression rather than in biochemical function of the protein.
But he is unduly alarmist when it comes to functional shift.
"Our conclusion was that while they may be able to pick here and there, it's extremely unlikely that there's going to be any kind of functional shift in where racing cars are built," he said.
When a functional shift is maintained for a long time, especially during the growth period, the sustained functional load on the mandible transforms the functional shift into structural asymmetry [20].
We argue that this functional shift can be aligend with effects of (pragmatic) adaptation and (sociolinguistic) appropriation.
The present study evaluates histologic changes to and expression of angiogenic factors in rats with mandibular functional shift (MFS).
