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In computing functional sensitivities with respect to shape, we use L2-type projections for computing boundary stresses and for geometric quantities such as the tangent field on the channel walls and the curvature; we show error estimates for the boundary stress and tangent field approximations.
Serums TSH, TgAb, and TPOAb levels were detected using the Abbott Architect (Abbott Laboratories, Abbott Park, IL, USA) with manufacturer's functional sensitivities (FS) of 0.01 mIU/L, 0.31 IU/mL, and 0.50 IU/mL, respectively.
From the definition of the adjoint operator (3), it follows that: < F'(p) δp, l> = < δp, ψ>. (4) That is, for all δp ∈ P the functional sensitivities can be computed via a single linear solution for ψ rather than repeated application of the linearized forward operator, F'(p) δp.
While receiving thyroxine, Tg assays with functional sensitivities of 0.2 0.3 ng/mL have a sensitivity and specificity of 54 63 % and 89 %, respectively, while assays with lower sensitivities of 0.02 0.1 ng/mL are associated with better sensitivity of 78 81 % but reduced specificity of 42 63 %.
The functional sensitivities for different inflammatory markers measured were as follows: CRP, 0.1 mg/L; TLC, 0.2; IL-6, 0.3 pg/mL; TNF-α, 1.8 pg/mL; MCP-1, 19.4 pg/mL; ICAM-1, 18.6 pg/mL; VCAM-1, 3.1 pg/mL; and E-selectin, 3.1 pg/mL.
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Although assays claiming to be highly sensitive state a functional sensitivity ≤0.1 μg/l, heterogeneity in assay reactivity may lead to differences in clinical performance.
This assay is highly specific and highly sensitive and has a functional sensitivity of 1.5 pg/ml [ 26].
Serum Tg was measured using a highly sensitive assay with a functional sensitivity of 0.1 μg/l.
Both are fully automated, sensitive, quantitative PCT assays with functional sensitivity of 0.06 ng/mL.
More recently, novel highly sensitive Tg assays (with a functional sensitivity ≤0.1 μg/l) have been developed and are commercially available.
The converged solutions of the state equations together with the steady state solution of the co-state equations are integrated along the domain boundary to uniquely determine the functional sensitivity derivatives with respect to the design function.
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