In the expert-driven functional selection, the biomarker candidates were selected as the several most differentially altered proteins belonging to the functional clusters providing the best integrated CAs.
Again, various subsets of amino acids including putative primitive amino acids should be tested for functional selection depending on the target function, because some putative new amino acids may be essential for some function.
An expert-driven functional selection approach was also performed to select individual proteins for comparison to our automated approach.
At the level of individual proteins, four out of the six candidates selected by the expert-driven functional selection were also identified in human plasma samples.
Functional selection for repair association was performed manually using the function tree of the IPA software (Qiagen), where genes under developmental and repair functional groups were identified.
Google ships a small but functional selection of watch faces with Android Wear.
Using genetic modification and functional selection, we developed a novel biosorbent from Genetically Engineered Bacillus subtilis (GEBS) cells.
The introduction of coordinated changes across multiple genetic elements, in conjunction with functional selection, presents an integrated approach for the modification of metabolism with benign physiological consequences.
Here, we describe the construction and optimization of a new phagemid display system that was designed to allow the functional selection of peptides that promote gene delivery from phagemids in a high display format.
Moreover, new technologies enabling more efficient genetic engineering of thermophiles were discussed, such as improved electroporation, ultrasound-mediated DNA delivery, as well as thermo-stable plasmids and functional selection systems.
To further increase the GT efficiency we applied the bi-partite approach, in which the DNA fragment for integration was split in two non-functional overlapping parts that via homologous recombination in vivo can form a functional selection marker.
