Sentence examples for functional screens from inspiring English sources

In addition, we included genes implicated in mitotic function through functional screens [ 44, 45] and genes involved in the structure and function of centrosomes [ 46], which are directly involved in chromosome segregation.

To identify proteins involved in this process we used functional screens by constructing loss-of-function mutants of genes encoding proteins predicted to be exported.

Importantly, we and others have demonstrated that these functional screens are able to identify essential functions linked to certain cancer phenotypes.

Functional screens are promising adjuncts to other objective tests.

Comparisons with functional screens show that MiSL predictions are enriched for SLs in multiple cancers.

To that end we are applying genome-wide expression analysis, chromatin immunoprecipitation, protein biochemistry, proteomics and functional screens.

The alternative of functional screens in intact animals, whether by chemical mutagenesis or gene targeting, remains a daunting undertaking.

Gene silencing through sequence-specific targeting of mRNAs by RNAi has enabled genome-wide functional screens in cultured cells and in vivo in model organisms.

To discover cell and molecular underpinnings of circuit tuning, the Shatz lab has conducted functional screens for genes regulated by neural activity.

In addition, functional screens revealed conserved host factors required for efficient viral translation, such as the ribosomal protein RACK1 and the release factor Pelo.

We also discuss new frontiers in pooled screens, including novel effector domains for functional screens and applications in the noncoding genome.