Further insight into Nkd1 function was recently gained using an integrated physical and functional screen to identify Wnt inhibitors [28].
No evidence of gain of function has been reported, but it is plausible, because a functional screen of the PARK2 splice variants has not been done yet.
Engineering such a probe requires a functional screen of many candidates.
Proteomics allows for rapid identification of the total MFGM proteins thereby providing a global functional screen of the lactating cell.
Here, we describe an enhanced functional screen in Xenopus designed for large-scale identification of genes controlling mesoderm formation.
The demonstrated LFD is specially designed with an integral imaging display (IID) with 83 × 83 viewpoints and a full-parallax holographic functional screen (HFS).
To identify opportunities to repurpose inhibitors against disease-associated mutant kinases, we conducted a large-scale functional screen of 183 known kinase inhibitors against 76 recombinant mutant kinases.
Guiding this development, we describe how a fluorescent substrate for hNET, 4- 4- dimethylamino)styryl)-N-methylpyridinium (ASP+), can be used to optimise vector design and serve as an in vitro functional screen.
These nucleases are used to create model cell lines, engineer metabolic pathways, produce transgenic animals and plants, perform genome-wide functional screen and, most importantly, treat human diseases that are difficult to tackle by traditional medications.
You might have to squint to witness this ridiculously tiny, functional screen printing press by artist Devin Smith in action.
Here we present an unbiased, genome-scale functional screen to identify regulators of INK4a.
