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In previous studies, a functional rotation mechanism was proposed for its functioning, according to which the three monomers undergo concerted conformational changes facilitating the extrusion of substrates.
Significant progress has been made in elucidating the three-dimensional structures of the homo-trimer complexes of AcrB-like transporters, and a three-step functional rotation was identified for this class of transporters.
Based on asymmetric tripartite structures of AcrB reported from multiple laboratories (Murakami et al. 2006; Seeger et al. 2006; Sennhauser et al. 2007), a peristaltic mechanism containing a three-step functional rotation has been proposed.
These changes in position and orientation of FHA in the knee should be considered in analyses of muscle function during human movement, which require moment arms to be defined relative to a functional rotation axis.
Manager Mike Scioscia would prefer a healthy and functional rotation over home-field advantage, but the Angels lost starters Garrett Richards and Tyler Skaggs to season-ending injuries in August, Matt Shoemaker is recovering from a rib-cage strain, and left-handers C.J. Wilson and Hector Santiago have been erratic.
In addition, the functional rotation mechanism evidenced for the multidrug efflux pump AcrB may also support this first hypothesis by the existence of three independent efflux sites acting step by step and capable to accept different substrates due to the site flexibility during the loose state [23].
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As we demonstrated in our series as well as in the series of Pondaag et al. [ 11], the results of functional external rotation of the shoulder are generally better than measurements of active external rotation in degrees because of compensatory mechanisms.
Functional external rotation of the shoulder was graded as per Al-Qattan's modification of the Mallet Score for external rotation [ 12] as shown in Table 2. Comparison between the two groups with regard to the glenohumeral external rotation measurements was done using the Mann-Whitney test.
Functional external rotation results of the two groups were compared using either the Fisher exact or the chi-square tests.
This study, firstly, investigates the effect of using an anatomical versus a functional axis of rotation (FAR) on knee adduction moment (KAM) in healthy subjects and patients with knee osteoarthritis (KOA).
HUX dynamically defines the functional center of rotation of the shoulder joint, the axis of the elbow joint, and also the center of the elbow joint with a skin "marker set" and seven segments: thorax, clavicles, upper arms, and forearms.
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