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In addition to NF-κB, signaling pathways involving MAP kinases have also been shown to play a functional role in the transduction of fHA signals [ 22, 34].
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Intracellular calcium plays an essential role in the transduction of most hormonal, neuronal and muscular stimuli.
Factors important in contributing to its utility as a phylogenetic marker may be due, at least in part, to the highly conserved, yet somewhat variable nature of its functional role in visual transduction.
In summary, the frequent and specific upregulation of pp125FAK in human breast cancer suggests an important functional role in neoplastic signal transduction and represents a potential marker for malignant transformation in breast epithelium and target for therapeutic interventions.
Importantly, they have highlighted the role of functional contractile muscle in the transduction of dynamic physical loads to form bones and joints.
Given the possibility that E650 may be involved in the transduction of conformational changes associated with calcium binding to trigger the channel's gating machinery, it will be important to further scrutinize its functional role in future studies.
The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.
Its essential role for the transduction of the RANKL signal was established in the late 1990s.
Mitochondria play a pivotal role in the signal transduction of apoptosis [32].
In the transduction of vertebrate hair cells, TMCs apparently took over the dominant role for mechanosensation.
Furthermore, as observed for Kv4.3 current [ 19], zShal3 current was also largely modulated by PKC activation, suggesting that a similar functional role for signal transduction-mediated modulation of A-type current may exist in zebrafish.
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