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The DUF283 domain displays affinity to bind the double-stranded RNA-binding domains of the A. thaliana dsRNA binding proteins (DRBs) [ 15] suggesting a functional role in the selection of the small RNA processing pathway.
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This, combined with the overall stabilizing selection on horizontally transferred gpsA genes (see Results), implies that the acquired genes are likely to have inherited their original functional role in the biosynthesis of bacterial membrane lipids.
Since the efficiency of NMD for degrading mutant mRNAs from target genes is highly variable, we recently proposed that NMD may therefore play an important role in the selection of target gene mutations with a functional role in MSI carcinogenesis [14].
Meek will play an instrumental role in the selection of a Project Canvas chief executive.
AIRE is a transcriptional regulator playing a functional role in thymocyte education and negative selection by controlling the expression of peripheral antigens in the thymus.
AIRE is a transcriptional regulator primarily expressed in medullary thymic epithelial cells, playing a functional role in thymocyte education and negative selection by controlling the expression of peripheral antigens in the thymus [ 5].
In summary, despite small numbers in some studied populations, we found evidence for signatures of recent selection in the Biaka Western Pygmies in genomic regions including CUL5, TRIM5, and TSG101 all of which have a functional role in HIV restriction; and for old selection in the genomic region containing PARD3B, a gene identified by a GWAS.
Genomes that have experienced selective pressure due to their functional role in phenotypic diversity contain unique patterns of genetic diversity called signatures of selection (Oleksyk et al. 2010).
The second that morphological changes that did play functional roles in bipedalism were the result of selection for that behavior—has not been previously explored and represents a major gap in our understanding of hominin hip evolution.
For the murine form this loop is almost exclusively subject to high selection, which suggests that this part of the structure has a key functional role in these small peptides.
The mitochondrial genome is a likely target for selection in this system due to its functional role in metabolism.
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