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Brodin, P., Lakshmikanth, T., Johansson, S., Karre, K. & Hoglund, P. The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.
In the context of endothelial biology, the balance between Ang-1 and Ang-2 regulates the functional responsiveness of the endothelium.
The functional responsiveness of the undirected differentiation pathway in H7 cells was therefore associated with a 3-fold increase in VGCC-dependent Ca2+ signalling (Figure 3A).
In summary, this study found that chronic alcohol intake significantly impedes the ability of opioid peptides to endocytose MOR, which leads to a decrease in the functional responsiveness of MOR and behavioral antinociceptive tolerance.
We next assessed the functional responsiveness of MOR to opioid in the spinal cord as well as several brain regions in rats that had been drinking water or ethanol.
If this analysis is done in single MHC class I mice, a comprehensive picture of which Ly49/MHC class I interactions that lead to functional responsiveness would be obtained.
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Even partial inhibition of betaARK1 activity enhances beta-adrenergic receptor signaling leading to improved functional catecholamine responsiveness.
RNP recovered from both viral variants exhibited stable complex formation with HSP72 despite loss of functional HSP72 responsiveness by the 4D variant.
Our data suggest the possibility that VDR activation modulates CCR6 expression and leads to a functional hypo-responsiveness to CCL20.
Functional non-responsiveness of T cells, despite physical presence of very few T cells as measured here, has been described as T cell "anergy", associated with a disturbed intracellular signaling of diacylglycerol [19].
T helper cells from peptide non-treated mice displayed a strong expansion upon LCMV infection (>1000 fold, Figure 1A), whereas T helper cells from peptide treated mice were few and showed no expansion (<2 fold, Figure 1A), implying functional non-responsiveness of those T cells.
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